Abstract Cancer stem-like cells (CSC) contribute to therapy resistance and recurrence.Focal adhesion kinase (FAK) has a role in CSC regulation.We determined the effect of FAK inhibition on breast CSC activity alone and in combination with adjuvant therapies.FAK inhibition reduced CSC activity and self-renewal across all molecular subtypes in primar
Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG–PLA micelle
Yanan Shi,1,2,* Wan Huang,1,* Rongcai Liang,1–3 Kaoxiang Sun,2,3 Fangxi Zhang,2,3 Wanhui Liu,2,3 Youxin Li1–31College of Life Science, Jilin University, Changchun, China; 2State Key Laboratory of Long-acting and Targeting Drug Delivery System, Luye Pharmaceutical Co, Ltd, Yantai, China; 3School of Pharmacy, Yantai University, Ya
Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma
The transformation of a benign hemangioma into a malignant angiosarcoma has been rarely reported, with only 11 cases reported in the literature.There have been no reports of malignant transformation of hemangioma into angiosarcoma in association with epithelioid hemangioendothelioma, to our knowledge.The existence of precursor malignancies in the t